Artemisia absinthium: the Bohemian

by Angeliki Barouti

“Thy secret pleasure turns to open shame, Thy private feasting to a public fast,Thy smoothing titles to a ragged name, Thy sugared tongue to bitter wormwood taste”
-William Shakespeare

Artemisia absinthium

Artemisia absinthium has always been a highly popular plant and is mentioned in many herbal, religious and art books for its medicinal properties, bitter taste and the legendary drink absinthe.

A. absinthium L. belongs to the Asteraceae, known for its impressive flowering plants, daisies and asters, with over than 32,000 species. Within this diverse family many traditional medicines, herbal preparations and poisons exist [1].

Names for wormwood across the world, absinthium
Names for wormwood across the world

The origin of the name is probably from the Greek Goddess Artemis who said to have discovered the plant’s properties, and the Greek word apsinthion, meaning “undrinkable” [2]. The plant is commonly known by the name wormwood, green ginger, but there are also other folk names across the countries [3].


Artemisia absinthium L., drawing of plant, flowers, seeds and fruits, by W. Muller 1885
Artemisia absinthium L., drawing of plant, flowers, seeds and fruits, by W. Muller 1885

It is an aromatic, hardy, perennial sub-shrub plant with erect, woody, medium size stems bear alternate, and silvery leaves with silky soft hairs that produce the essential oil of the plant. Small yellowish flowers bloom in late summer, usually from July to October [3]. A. absinthium is native to Europe, parts of Asia, N. Africa and it was introduced to North America in 1841 [4]. Now it is widely cultivated and sold excessively in herb markets in Venezuela, Panama and Costa Rica [5].


The therapeutic use of wormwood chronicles back to ancient times. Wormwood was documented in the Ebers Papyrus, an Egyptian medical papyrus of herbal knowledge dating from about 1550 B.C.E.. In Greece the mathematician and philosopher, Pythagoras (569–475 B.C.E.), recommended wine-soaked wormwood leaves to alleviate labor pains and Hippocrates (460–377 B.C.E.) used it for the treatment of menstrual pain and rheumatism. Pliny the Elder (23–79 C.E.), a Roman naturalist, scientist and philosopher, also mentioned extracts of wormwood in his “encyclopedia”, Historia Naturalis [6].

Bataille, Nicolas, tapestry, 14th Century
The third trumpet and the wormwood, Bataille Nicolas, tapestry, 14th Century

Wormwood is also mentioned several times in the Bible. In the Old Testament is referred as a punishment, “Behold, I will feed this people wormwood and give them poisoned water to drink”, “He has filled me with bitterness; He has intoxicated me with wormwood” (Jeremiah 9:15, Lamentations 3:15) and injustice, “You who turn justice into wormwood and cast righteousness to the ground”, (Amos 5:7). In the Revelations 8:11 wormwood is the name of a star that when the third angel sounds his trumpet will fall from the sky and turn the waters bitter.

In the middle ages, wormwood was very popular and it was used for stomach pains and sickness, as a purge, vermifuge, moth repellant and general pesticide. Also because of its bitter taste, women were applying it to their nipples to encourage the weaning of their babies. William Shakespeare inspired by this and referred to wormwood in Romeo and Juliet (Act 1, Scene 3) where Juliet’s childhood nurse said: “When it did taste the wormwood on the nipple of my dug and felt it bitter, pretty fool, to see it tetchy and fall out with the dug” [6, 7].


Artemisia absinthium L. by Jan Christiaan Sepp 1844
Artemisia absinthium L. by Jan Christiaan Sepp 1844

The active components are bitter substances, the sesquiterpene lactones, with absinthin and artabsin being the main compounds, flavonoids, essential oil and resins. The essential oil is a mixture of many volatile compounds with high therapeutic potential [3, 8]. However, its composition varies qualitatively and quantitative from a region to another, creating different chemotypes, for the same plant. For example α-thujone can be found usually in plants grown below 1,000m above the sea level, for example in Europe and Morocco where (z)-epoxyocimene above 1,000m, in Croatia, France and Iberian peninsula. Chamazulene is the main component in chemotypes from Turkey and Tunise, camphor from Turkey and Ethiopia, while trans-sabinylacetat and chrysanthenyl-acetate can be found in many different chemotypes. Other components re¬ported are β-thujone, myrcene, β-pinene, 1,8-cineole, camphor, and other hydrocarbon monoter¬penes [3, 9-14].

Medicinal Uses

Civilizations for the past thousand years have used the aerial parts of wormwood, such flower, seeds, fruit, leaves, stems, in many formulations, teas, powder, tincture or its essential oil to treat all manner of illness and inflammation.

Wormwood herba
Wormwood herba

Traditionally, wormwood has a unique position in Unani, a Perso-Arabic medicine as it was used for diverse diseases like jaundice, fever, hepatitis, cirrhosis, epilepsy, gout, rheumatism, dyspepsia, diarrhoea, inflammatory bowel disease (IBD), colitis, anorexia, ascites, haemorrhoids, weak memory, helminthic infestation, eye diseases, otorrhoea , menstrual disorders, scorpion bites, insect repellent and for even more [15, 16].

Its use expands to all continents. In Puerto Rico and Jamaica, it is taken with empty stomach for its anthelmintic properties and fresh and dry branches are used to repel mosquitoes and moths 5. In central Italy the poultice of aerial parts are applied on tendon inflammations [17]. In Pakistan where 7.1 million people suffer from diabetes mellitus the public health care system is unsufficient, patients are using various wormwood as an alternative antidiabetic plants [18]. Additionally, Traditional Chinese medicine practitioners use the plant for treating acute bacillary dysentery, cancers and neurodegenerative diseases 19. Other traditional uses are as astringents, cardiac stimulant, diuretic, emmanagogue, antiseptic, antidepressive and antispasmodic [20, 38], most of them can be explained while looking through of some wormwood’s biological properties.

Biological Activities

Wormwood has a strongly bitter flavor that can affect the feed intake and assists, rather than stimulating, the digestion through gastric juice secration (eupeptic). In addition, it was found out that wormwood belongs to a specific group of eupeptics that has cardiovascular therapeutic uses outside of their digestive ones because it enhances vascular tonus and thus reduces the load on the heart [21].

Anti-inflammatory effects
Some of its natural components such as sesquiterpenes and flavonoids are well known to possess anti-inflammatory and analgesic activity through a mechanism associated with synthesis or release of inflammatory mediators such as the histamine, serotonin, bradykinins and prostaglandins [22]. In addition wormwood found to be beneficial in Crohn’s disease (CD), by improving not only the symptoms but also the mood and quality of life of all patients [23, 24].

Antioxidant effects
A. absinthium is a source of many secondary metabolites that can diminish or prevent oxidation and thus, restrain the damage of radicals in tissue.
Wormwood was used widely in China as neuroprotective, for the improvement of memory. Its extracts were found to potentiate the nerve growth factor and protect from brain ischemia and oxidative stress. As a result, it could be useful as a complementary treatment of stroke, the most universal cause of disability [25, 26]. However, the evidence for this is far too preliminary and there clearly is no evidence that this could be a main or acute.

Antibacterial and antifungal activity reported
Antibacterial and antifungal activity reported

Antimicrobial effects
A.absinthium, among many other plants, has been highly studied the past years due to the increasing resistance in synthetic antibiotics. Wormwood has a broad spectrum of antimicrobial inhibition against a variety of bacteria, especially the gram positive ones and fungi [27-30, 9 ,10].
Plant extract consist complex mixtures, and it must be under consideration that components can act synergesticly or antagonictly. However it is suggested that several effects can be attributed to some major components like (Z)-epoxyocimene, chamazulene, β –thujone, camphor or caryiophyllene [31].

Antiparasitic Activity
As its common name indicates, wormwood was and still is an effective anthelmintic agent used to destroy intestinal worms. Besides this activity, wormwood has antiprotozoal uses. It inhibits Trypanosoma brucei, T. cruzi and T. congolese, possibly due to the components trans-caryophyllene and dihydrochamazulene [36]. These parasites are responsible for two severe diseases, the Chagas disease in Latin America and the African trypanosomiasis that have infected hundreds of millions of people. Antileishmanial activity against Leishmania infantum, L. aethiopica and L. donovani has been also reported [33, 32] and growth inhibitory effects against the brain damaging amoeba Naegleria fowleri [34]. In addition wormwood has antimalarian activity, like its famous relative species A. annua, against Plasmodium falciparum and P. bergei [35]. Furthermore, the essential oil inhibits Trichominas vaginalis, due to trans-caryophyllene and (-)-cis-chrysanthenol [36]. Trichomoniasis is among the world’s most common sexually transmitted diseases with more than 276 million cases per year [37].

Antitumor activity
A.absinthium is also a promising plant for the treatment of cancer. Ethanolic extracts from roots, leaves, seeds and herba are reported to be cytotoxic, promoting apoptosis to various types of cancer cells. The cytotoxic effects are possibibly due to the presence of trans-caryophyllene, chamazulene and germanene D [20].

Art and Absinthe

Glass with absinthe served with a cube of sugar
Glass with absinthe served with a cube of sugar

A. absinthium is the main ingredient of the famous alcoholic drink named absinthe. The origin of the famous bitter drink is Couvet in Switzerland by Dr. Pierre Ordinaire but its popularity started in 1805 when it was transferred in a distillery in France [39]. Initially absinthe was expensive but due to wars in the 19th century its usage increased. In the war of Algeria absinthe was given to the soldiers, protectively for malaria and helminthiasis, as antiseptic and to raise the fighting spirit [40, 41].

By the 19th century the absinthe, or “green fairy”, had become the most favorable drink in France and it was consumed by all people, especially the Bohemian class. Absinthe was the symbol of la vie bohème, artists and intellectuals preferred it for its emerald colour and because they thought it was assisting in the flow of ideas and creativity. From the 1867, around 5 o’clock in the evening, people were gathering, sipping large amounts of absinthe and reaching levels of intoxication to celebrate l’heure verte (the green hour) [41, 42, 43].

Vincent van Gogh - Still Life with Absinthe 1887
Vincent van Gogh – Café table with absinthe, 1887

For many artists, writers and poets absinthe was an element of their daily routine and this is depicted in many of their works. In the late 19th century Edouard Manet and Edgar Degas, founders of impressionism, painted the ritual of drinking absinthe. Furthermore, the impressionist painter Vincent van Gogh got addicted to absinthe and this slow poisoning deteriorate his health [39,42]. Herni Toulouse-Lautrec, Paul Gaugin, friends of Van Gogh, and Pablo Picasso had also the green fairy as an inspiration for their works. Additionally, in the literature field Oscar Wilde, Paul Verlaine, Arthur Rimbaud, Charles Baudelaire, Edgar Alan Poe, Oscar Wilde and Ernest Hemingway were devotees of absinthe [39, 44-46].

“After the first glass you see things as you wish they were. After the second, you see things as they are not. Finally you see things as they really are, and that is the most horrible thing in the world”
-Oscar Wilde

Final Thoughts

Pablo Picasso, "The absinthe drinker", 1901
Pablo Picasso, “The absinthe drinker”, 1901

A. absinthium L. is a significant medicinal plant with therapeutic uses dating back to ancient times. Experimental studies have shown that it demonstrates numerous different biological activities that encourage a potential on modern therapeutic use. Its special characteristics are its bitterness and aroma which have been an inspiration to many folk stories and to the artistic and literary set of belle époque. Undoubtedly there is mysticism surrounding wormwood and this mystery makes it one of the most interesting plants existing.


  1. “The Plant List: Compositae”. Royal Botanic Gardens Kew and Missouri Botanic Garden. Retrieved 18 November 2016.
  2. C.W.Wright, C. (2001) Artemisia, 1st edition, London, Taylor & Francis Ltd
  3. Beigh, Y. A. and Ganai, A. M. (2017) ‘Potential of Wormwood (Artemisia absinthium Linn.) herb for use as additive in livestock feeding: A review’, The Pharma Innovation Journal, 6(8), pp. 176–187.
  4. Maw, M. G., et al. (1985). The biology of Canadian weeds.66.Artemisia absinthium L. Canadian Journal of Plant Science.65 (2): 389-400.
  5. Lana, D. C. and Whelan, J. S. (2008) ‘Tropical american plants in the treatment of infectious diseases’, Journal of Dietary Supplements, 5(4), pp. 349–372. doi: 10.1080/19390210802519648.
  6. Padosch, S. A., et al. (2006) ‘Substance Abuse Treatment , Prevention , and Policy Absinthism : a fictitious 19th century syndrome with present impact’, Substance abuse treatment prevention and policy, 14(1), pp. 1–14. doi: 10.1186/1747-597X-1-
  7. Hajar R. (2012). The Air of History (Part II) Medicine in the Middle Ages. Heart views : the official journal of the Gulf Heart Association, 13(4), 158–162.
  8. Goud, B. J., et al. (2015) ‘a Review on History, Controversy, Traditional Use, Ethnobotany, Phytochemistry and Pharmacology of Artemisia absinthium Linn’, Advanced Research in Engineering and Applied Sciences, 4(5), pp. 77–107.
  9. Kordali, S. et al. (2005). Determination of the Chemical Composition and Antioxidant Activity of the Essential Oil of Artemisia dracunculus and of the Antifungal and Antibacterial Activities of Turkish Artemisia absinthium , A. dracunculus , Artemisia santonicum , and Artemisia spicigera Essential Oils. Journal of agricultural and food chemistry. 53. 9452-8. 10.1021/jf0516538.
  10. Kordali, S. et al. (2005). Screening of Chemical Composition and Antifungal and Antioxidant Activities of the Essential Oils from Three Turkish Artemisia Species. Journal of agricultural and food chemistry. 53. 1408-16. 10.1021/jf048429n.
  11. Judžentiene, A. (2016) ‘Wormwood (Artemisia absinthium L.) oils’, Essential Oils in Food Preservation, Flavor and Safety, pp. 849–856. doi: 10.1016/B978-0-12-416641-7.00097-3.
  12. Derwich, E. et al. (2009). Chemical compositions and insectisidal activity of essential oils of three plants Artemisia SP: Artemisia herba-alba, Artemisia absinthium and Artemisia Pontica (Morocco). Electronic Journal of Environmental, Agricultural and Food Chemistry.
  13. Martín, L. et al. (2011). Supercritical fluid extraction of wormwood (Artemisia absinthium L.). The Journal of Supercritical Fluids. 56. 64-71. 10.1016/j.supflu.2010.11.017.
  14. Orava, A. et al. (2006). Composition of the essential oil of Artemisia absinthium L. of different geographical origin. Proc. Estonian Acad. Sci. Chem. 55.
  15. Ansari, S., Shamshi, Y. and Khan, Q. A. (2019) ‘a Review of Artemisia absinthium , Linn. (Afsanteen) With Special Reference of Unani Medicine’, Journal of Pharmaceutical & Scientific Innovation, 8(1), pp. 11–18. doi: 10.7897/2277-4572.081119.
  16. Tafti, L. D. et al. (2017) ‘Traditional persian topical medications for gastrointestinal diseases’, Iranian Journal of Basic Medical Sciences, 20(3), pp. 222–241. doi: 10.22038/ijbms.2017.8349.
  17. Guarrera, P. (2005). Traditional phytotherapy in Central Italy (Marche, Abruzzo, and Latium). Fitoterapia. 76. 1-25. 10.1016/j.fitote.2004.09.006.
  18. Chinsembu, K. C. (2019). Diabetes mellitus and nature’s pharmacy of putative antidiabetic plants. Journal of Herbal Medicine, 15, 100230.
  19. Parekh, H. S., Liu, G. and Wei, M. Q. (2009) ‘A new dawn for the use of traditional Chinese medicine in cancer therapy’, Molecular Cancer, 8, pp. 1–8. doi: 10.1186/1476-4598-8-21.
  20. Taleghani, A., Emami, S. A. and Tayarani-Najaran, Z. (2020) ‘Artemisia: a promising plant for the treatment of cancer’, Bioorganic and Medicinal Chemistry, 28(1). doi: 10.1016/j.bmc.2019.115180.
  21. McMullen, M. K., Whitehouse, J. M. and Towell, A. (2015) ‘Bitters: Time for a new paradigm’, Evidence-based Complementary and Alternative Medicine, 2015. doi: 10.1155/2015/670504.
  22. Krebs, S., Omer, T. N., & Omer, B. (2010). Wormwood (Artemisia absinthium ) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn’s disease—A controlled clinical trial. Phytomedicine, 17(5), 305–309. 2009.10.013
  23. Omer, B., Krebs, S., Omer, H., & Noor, T. O. (2007). Steroid-sparing effect of wormwood (Artemisia absinthium ) in Crohn’s disease: A double-blind placebo-controlled study. Phytomedicine, 14(2), 87–95. https://doi. org/10.1016/j.phymed.2007.01.001
  24. Naß, J. and Efferth, T. (2018) ‘The activity of Artemisia spp. and their constituents against Trypanosomiasis’, Phytomedicine, 47(December 2017), pp. 184–191. doi: 10.1016/j.phymed.2018.06.002.
  25. Li, Y. and Ohizumi, Y. (2004) ‘Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of Paraguay and Thailand’, Yakugaku Zasshi, 124(7), pp. 417–424. doi: 10.1248/yakushi.124.417.
  26. Bora, K. S. and Sharma, A. (2010) ‘Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury’, Journal of Ethnopharmacology. Elsevier Ireland Ltd, 129(3), pp. 403–409. doi: 10.1016/j.jep.2010.04.030.
  27. Blagojević, P. et al. (2006) ‘Chemical composition of the essential oils of Serbian wild-growing Artemisia absinthium and Artemisia vulgaris’, Journal of Agricultural and Food Chemistry, 54(13), pp. 4780–4789. doi: 10.1021/jf060123o.
  28. Juteau, F. et al. (2003) ‘Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France,’ Planta Medica, vol. 69, no. 2, pp. 158–161
  29. Alzoreky, N.S., Nakahara, K., 2003. Antibacterial activity of extracts from some edible plants commonly consumed in Asia. International Journal of Food Microbiology 80, 223–230. doi:10.1016/S0168-1605(02)00169-1
  30. Erdoǧrul, Ö. T. (2002) ‘Antibacterial activities of some plant extracts used in folk medicine’, Pharmaceutical Biology, 40(4), pp. 269–273. doi: 10.1076/phbi.
  31. Kordali, S. et al. (2006) ‘Toxicity of essential oils isolated from three Artemisia species and some of their major components to granary weevil, Sitophilus granarius (L.) (Coleoptera: Curculionidae)’, Industrial Crops and Products, 23(2), pp. 162–170. doi: 10.1016/j.indcrop.2005.05.005.
  32. Tariku, Y. et al. (2011) In vitro evaluation of antileishmanial activity and toxicity of essential oils of Artemisia absinthium and Echinops kebericho. Chem Biodivers 2 8(4): 614-23.
  33. Valdés, A. F. C. et al. (2008) ‘In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L’, Memorias do Instituto Oswaldo Cruz, 103(6), pp. 615–618. doi: 10.1590/s0074-02762008000600019.
  34. Mendiola, J. et al. (1991) ‘Extracts of Artemisia abrotanum and Artemisia absinthium inhibit growth of Naegleria fowleri in vitro’, Transactions of The Royal Society of Tropical Medicine and Hygiene, 85(1), pp. 78–79. doi: 10.1016/0035-9203(91)90165-U.
  35. Zafab, M. M. et al., (1990) ‘Screening of Artemisia absinthium for antimalarial effects on Plasmodium berghei in mice: A preliminary report’, Journal of Ethnopharmacology, 30(2), pp. 223–226. doi:
  36. Martínez-Díaz, R. A. et al. (2015) ‘Trypanocidal, trichomonacidal and cytotoxic components of cultivated Artemisia absinthium Linnaeus (Asteraceae) essential oil’, Memorias do Instituto Oswaldo Cruz, 110(5), pp. 693–699. doi: 10.1590/0074-02760140129.
  37. World Health Organization W. Global incidence and prevalence of selected curable sexually transmitted infections. 2008. ISBN 978 92 4 150383 9
  38. Goud, B. J., Dwarakanath.V and B.K.Chikka, S. (2015) ‘a Review on History, Controversy, Traditional Use, Ethnobotany, Phytochemistry and Pharmacology of Artemisia absinthium Linn’, Advanced Research in Engineering and Applied Sciences, 4(5), pp. 77–107.
  39. Lachenmeier, D. W. et al. (2006) ‘Absinthe – A review’, Critical Reviews in Food Science and Nutrition, 46(5), pp. 365–377. doi: 10.1080/10408690590957322.
  40. Frances R. Frankenburg, F.R. (2014) Brain-Robbers: How Alcohol, Cocaine, Nicotine, and Opiates Have Changed Human History, 1st Edition , Praeger
  41. Vogt, D. D. and Montagne, M. (1982) ‘Absinthe: Behind the Emerald mask’, Substance Use and Misuse, 17(6), pp. 1015–1029. doi: 10.3109/10826088209057772.
  42. Padosch, S. A., Lachenmeier, D. W. and Kröner, L. U. (2006) ‘Substance Abuse Treatment, Prevention , and Policy Absinthism : a fictitious 19th century syndrome with present impact’, Substance abuse treatment prevention and policy, 14(1), pp. 1–14. doi: 10.1186/1747-597X-1-Received
  43. Monroe, R. R. (1992) Creative Brainstorms: The Relationship Between Madness and Genius (Frontiers of Consciousness), 1st edition, Irvington Pub
  44. Rekand, T. (2006) ‘Absinthe, The Nervous System and Painting’, International Review of Neurobiology, 74(06), pp. 271–278. doi: 10.1016/S0074-7742(06)74019-3.
  45. Lanier, D. (1995). ‘‘Absinthe. The Cocaine of the Nineteenth Century.’’ JeVerson, McFarland, North Carolina.
  46. Conrad, B. (1988). “Absinthe History in a Bottle”. Chronicle books, San Francisco


Image 1 Artemisia absinthium: By AfroBrazilian [CC BY-SA 3.0 (], via Wikimedia Commons, available from:

Image 2 Names of wormwood across the world: By the author

Image 3 Artemisia absinthium L., drawing of plant, flowers, seeds and fruits, by W. Muller 1885: Public domain, available from:

Image 4 The third trumpet and the wormwood, Bataille Nicolas, tapestry, 14th Century: Public domain, available from:

Image 5 Artemisia absinthium L. by Jan Christiaan Sepp 1844: Public domain, available from:

Image 6 Wormwood herba: By MichielSt [CC BY-SA 4.0 (], via Wikimedia Commons, available from:

Image 7 Antibacterial and antifungal activity reported: By the author

Image 8 Glass with absinthe served with a cube of sugar: Eric Litton [CC BY-SA 2.5 (], via Wikimedia Commons, available from:

Image 9 Vincent van Gogh, “Café table with absinthe”, 1887: Public domain,

Image 10 Pablo Picasso, “The absinthe drinker: Public domain,